Wee1 Inhibitor AZD1775 Combined with Cisplatin Potentiates Anticancer Activity against Gastric Cancer by Increasing DNA Damage and Cell Apoptosis

Based on the mechanisms by which Wee1 inhibitor and cisplatin played their own role, a promising strategy of Wee1 inhibitor combined with cisplatin was proposed, which was investigated in gastric cancer (GC). Either Wee1 inhibitor AZD1775 or cisplatin alone had a certain inhibitory effect on in vitr...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Chen, Dongshao, Lin, Xiaoting, Gao, Jing, Shen, Lin, Li, Zhongwu, Dong, Bin, Zhang, Cheng, Zhang, Xiaotian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011131/
https://ncbi.nlm.nih.gov/pubmed/29977914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5813292
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