A small molecule inhibitor of WEE1, AZD1775, synergizes with olaparib by impairing homologous recombination and enhancing DNA damage and apoptosis in acute leukemia

Although some patients with acute leukemia have good prognoses, the prognosis of adult and pediatric patients who relapse or cannot tolerate standard chemotherapy is poor. Inhibition of WEE1 with AZD1775 has been shown to sensitize cancer cells to genotoxic chemotherapies including cytarabine in AML...

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Publicado en:Mol Cancer Ther
Autores principales: Garcia, Tamara B., Snedeker, Jonathan C., Baturin, Dmitry, Gardner, Lori, Fosmire, Susan P., Zhou, Chengjing, Jordan, Craig T., Venkataraman, Sujatha, Vibhakar, Rajeev, Porter, Christopher C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628125/
https://ncbi.nlm.nih.gov/pubmed/28655785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0660
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