Targeting MYC-Driven Replication Stress in Medulloblastoma with AZD1775 and Gemcitabine

PURPOSE: MYC-driven medulloblastomas are highly aggressive childhood tumors with dismal outcomes and a lack of new treatment paradigms. We identified that targeting replication stress through WEE1 inhibition to suppress the S-phase replication checkpoint, combined with the attenuation of nucleotide...

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Bibliografiset tiedot
Julkaisussa:J Neurooncol
Päätekijät: Moreira, Daniel C, Venkataraman, Sujatha, Subramanian, Apurva, Desisto, John, Balakrishnan, Ilango, Prince, Eric, Pierce, Angela, Greisinger, Andrea, Green, Adam, Eberhardt, Charles G, Foreman, Nicholas K, Vibhakar, Rajeev
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291878/
https://ncbi.nlm.nih.gov/pubmed/32180106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03457-0
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