Turning liabilities into opportunities: Off-target based drug repurposing in cancer

מאת Palve, Vinayak, Liao, Yi, Remsing Rix, Lily L., Rix, Uwe
הוצא לאור ב Semin Cancer Biol (2020)

Chemoproteomics reveals novel protein and lipid kinase targets of clinical CDK4/6 inhibitors in lung cancer

מאת Sumi, Natalia J., Kuenzi, Brent M., Knezevic, Claire E., Rix, Lily L. Remsing, Rix, Uwe
הוצא לאור ב ACS Chem Biol (2015)

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia

מאת Kuenzi, Brent M., Remsing Rix, Lily L., Kinose, Fumi, Kroeger, Jodi L., Lancet, Jeffrey E., Padron, Eric, Rix, Uwe
הוצא לאור ב Sci Rep (2019)

Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach

מאת Fang, Bin, Izumi, Victoria, Remsing Rix, Lily L., Welsh, Eric, Pike, Ian, Reuther, Gary W., Haura, Eric B., Rix, Uwe, Koomen, John M.
הוצא לאור ב Proteomics (2020)

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition

מאת Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.
הוצא לאור ב Mol Oncol (2017)

GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells

מאת Remsing Rix, Lily L., Kuenzi, Brent M., Luo, Yunting, Remily-Wood, Elizabeth, Kinose, Fumi, Wright, Gabriela, Li, Jiannong, Koomen, John M., Haura, Eric B., Lawrence, Harshani R., Rix, Uwe
יצא לאור 2013

Dual targeting of WEE1 and PLK1 by AZD1775 elicits single agent cellular anticancer activity

מאת Wright, Gabriela, Golubeva, Volha, Remsing Rix, Lily L., Berndt, Norbert, Luo, Yunting, Ward, Grace A., Gray, Jhanelle E., Schonbrunn, Ernst, Lawrence, Harshani R., Monteiro, Alvaro N.A., Rix, Uwe
הוצא לאור ב ACS Chem Biol (2017)

Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

מאת Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe
הוצא לאור ב Mol Cell Proteomics (2018)

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model

מאת Sarcar, Bhaswati, Gimbrone, Nicholas T., Wright, Gabriela, Remsing Rix, Lily L., Gordian, Edna R., Rix, Uwe, Chiappori, Alberto A., Reuther, Gary W., Santiago‐Cardona, Pedro G., Muñoz‐Antonia, Teresita, Cress, William Douglas
הוצא לאור ב FEBS Open Bio (2019)

A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL

מאת Rix, Uwe, Colinge, Jacques, Blatt, Katharina, Gridling, Manuela, Remsing Rix, Lily L., Parapatics, Katja, Cerny-Reiterer, Sabine, Burkard, Thomas R., Jäger, Ulrich, Melo, Junia V., Bennett, Keiryn L., Valent, Peter, Superti-Furga, Giulio
יצא לאור 2013

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

מאת Kim, Jae-Young, Welsh, Eric A., Oguz, Umut, Fang, Bin, Bai, Yun, Kinose, Fumi, Bronk, Crystina, Remsing Rix, Lily L., Beg, Amer A., Rix, Uwe, Eschrich, Steven A., Koomen, John M., Haura, Eric B.
יצא לאור 2013

Proteome-wide profiling of clinical PARP inhibitors reveals compound-specific secondary targets

מאת Knezevic, Claire E., Wright, Gabriela, Rix, Lily L. Remsing, Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe
הוצא לאור ב Cell Chem Biol (2016)

PAXIP1 potentiates the combination of WEE1 inhibitor AZD1775 and platinum agents in lung cancer

מאת Jhuraney, Ankita, Woods, Nicholas T., Wright, Gabriela, Rix, Lily, Kinose, Fumi, Kroeger, Jodi L., Remily-Wood, Elizabeth, Cress, W. Douglas, Koomen, John M., Brantley, Stephen G., Gray, Jhanelle E., Haura, Eric B., Rix, Uwe, Monteiro, Alvaro N.
הוצא לאור ב Mol Cancer Ther (2016)

Divergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative effects on individual targets

מאת Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Rix, Lily L. Remsing, Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe
הוצא לאור ב Cell Chem Biol (2019)