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Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
GSK3α has been identified as a new target in the treatment of acute myeloid leukemia (AML). However, most GSK3 inhibitors lack specificity for GSK3α over GSK3β and other kinases. We have previously shown in lung cancer cells that GSK3α and to a lesser extent GSK3β are inhibited by the advanced clini...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6345777/ https://ncbi.nlm.nih.gov/pubmed/30679640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37174-6 |
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