Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

Lung cancer is associated with high prevalence and mortality, and despite significant successes with targeted drugs in genomically defined subsets of lung cancer and immunotherapy, the majority of patients currently does not benefit from these therapies. Through a targeted drug screen, we found the...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Proteomics
Hoofdauteurs: Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283294/
https://ncbi.nlm.nih.gov/pubmed/30217950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000713
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