Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

Lung cancer is associated with high prevalence and mortality, and despite significant successes with targeted drugs in genomically defined subsets of lung cancer and immunotherapy, the majority of patients currently does not benefit from these therapies. Through a targeted drug screen, we found the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell Proteomics
Auteurs principaux: Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283294/
https://ncbi.nlm.nih.gov/pubmed/30217950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000713
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