Divergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative effects on individual targets

Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the targets and...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Rix, Lily L. Remsing, Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754293/
https://ncbi.nlm.nih.gov/pubmed/31257184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.06.003
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