Polypharmacology-based ceritinib repurposing using integrated functional proteomics

Targeted drugs are effective when directly inhibiting strong disease drivers, but only a small fraction of diseases feature defined actionable drivers. Alternatively, network-based approaches can uncover new therapeutic opportunities. Applying an integrated phenotypic screening, chemical and phospho...

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Udgivet i:Nat Chem Biol
Main Authors: Kuenzi, B.M., Remsing Rix, L.L., Stewart, P.A., Fang, B., Kinose, F., Bryant, A.T., Boyle, T.A., Koomen, J.M., Haura, E.B., Rix, U.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909815/
https://ncbi.nlm.nih.gov/pubmed/28991240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2489
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