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Polypharmacology-based ceritinib repurposing using integrated functional proteomics
Targeted drugs are effective when directly inhibiting strong disease drivers, but only a small fraction of diseases feature defined actionable drivers. Alternatively, network-based approaches can uncover new therapeutic opportunities. Applying an integrated phenotypic screening, chemical and phospho...
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| 出版年: | Nat Chem Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909815/ https://ncbi.nlm.nih.gov/pubmed/28991240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2489 |
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