Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

TANK-binding kinase 1 (TBK1) has emerged as a novel therapeutic target for unspecified subset of lung cancers. TBK1 reportedly mediates prosurvival signaling by activating NF-κB and AKT. However, we observed that TBK1 knockdown also decreased viability of cells expressing constitutively active NF-κB...

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Detalhes bibliográficos
Main Authors: Kim, Jae-Young, Welsh, Eric A., Oguz, Umut, Fang, Bin, Bai, Yun, Kinose, Fumi, Bronk, Crystina, Remsing Rix, Lily L., Beg, Amer A., Rix, Uwe, Eschrich, Steven A., Koomen, John M., Haura, Eric B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725062/
https://ncbi.nlm.nih.gov/pubmed/23836654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220674110
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