High-throughput compatible FRET based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

Por Arnst, Jamie L., Davies, Christopher W., Raja, Srikumar M., Das, Chittaranjan, Natarajan, Amarnath
Publicado em 2013

Encapsulation of poorly soluble drugs in polymer-drug conjugates: effect of dual-drug nanoformulations on cancer therapy

Por Senanayake, Thulani H., Lu, Yaman, Bohling, Anna, Raja, Srikumar, Band, Hamid, Vinogradov, Serguei V.
Publicado em 2014

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src(@)

Por Chung, Byung Min, Raja, Srikumar M, Clubb, Robert J, Tu, Chun, George, Manju, Band, Vimla, Band, Hamid
Publicado em 2009

Mechanisms of Trastuzumab resistance in ErbB2-driven breast cancer and newer opportunities to overcome therapy resistance

Por Bailey, Tameka A., Luan, Haitao, Clubb, Robert J., Naramura, Mayumi, Band, Vimla, Raja, Srikumar M., Band, Hamid
Publicado em 2011

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

Por Metkar, Sunil S., Wang, Baikun, Ebbs, Michelle L., Kim, Jin H., Lee, Yong J., Raja, Srikumar M., Froelich, Christopher J.
Publicado em 2003

A Comprehensive, Multi-Scale Dynamical Model of ErbB Receptor Signal Transduction in Human Mammary Epithelial Cells

Por Helikar, Tomáš, Kochi, Naomi, Kowal, Bryan, Dimri, Manjari, Naramura, Mayumi, Raja, Srikumar M., Band, Vimla, Band, Hamid, Rogers, Jim A.
Publicado em 2013

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

Por Naramura, Mayumi, Nadeau, Scott, Mohapatra, Bhopal, Ahmad, Gulzar, Mukhopadhyay, Chandrani, Sattler, Martin, Raja, Srikumar M, Natarajan, Amarnath, Band, Vimla, Band, Hamid
Publicado em 2011

Induction of Cancer Cell Death by Self-assembling Nanostructures Incorporating a Cytotoxic Peptide

Por Standley, Stephany M., Toft, Daniel J., Cheng, Hao, Soukasene, Stephen, Chen, Jing, Raja, Srikumar M., Band, Vimla, Band, Hamid, Cryns, Vincent L., Stupp, Samuel I.
Publicado em 2010

A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathwaydependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer ce...

Por Raja, Srikumar M., Clubb, Robert J., Bhattacharyya, Mitra, Dimri, Manjari, Cheng, Hao, Pan, Wei, Ortega-Cava, Cesar, Lakku-Reddi, Alagarsamy, Naramura, Mayumi, Band, Vimla, Band, Hamid
Publicado em 2008

ESCRT proteins: Double-edged regulators of cellular signaling

Por Tu, Chun, Ahmad, Gulzar, Mohapatra, Bhopal, Bhattacharyya, Sohinee, Ortega-Cava, Cesar F, Chung, Byung Min, Wagner, Kay-Uwe, Raja, Srikumar M, Naramura, Mayumi, Band, Vimla, Band, Hamid
Publicado em 2011

A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells

Por Bailey, Tameka A., Luan, Haitao, Tom, Eric, Bielecki, Timothy Alan, Mohapatra, Bhopal, Ahmad, Gulzar, George, Manju, Kelly, David L., Natarajan, Amarnath, Raja, Srikumar M., Band, Vimla, Band, Hamid
Publicado em 2014

Anticancer activity of celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

Por Raja, Srikumar M, Clubb, Robert J, Ortega-Cava, Cesar, Williams, Stetson H, Bailey, Tameka A, Duan, Lei, Zhao, Xiangshan, Reddi, Alagarasamy L, Nyong, Abijah M, Natarajan, Amarnath, Band, Vimla, Band, Hamid
Publicado em 2011

Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition

Por Raja, Srikumar M., Desale, Swapnil S., Mohapatra, Bhopal, Luan, Haitao, Soni, Kruti, Zhang, Jinjin, Storck, Matthew A., Feng, Dan, Bielecki, Timothy A., Band, Vimla, Cohen, Samuel M., Bronich, Tatiana K., Band, Hamid
Publicado no Oncotarget (2016)

Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer

Por Ortega-Cava, Cesar F., Raja, Srikumar M., Laiq, Zenab, Bailey, Tameka A., Luan, Haitao, Mohapatra, Bhopal, Williams, Stetson H., Ericsson, Aaron C., Goswami, Rasna, Dimri, Manjari, Duan, Lei, Band, Vimla, Naramura, Mayumi, Band, Hamid
Publicado em 2011

Polypeptide-based nanogels co-encapsulating a synergistic combination of Doxorubicin with 17-AAG show potent anti-tumor activity in ErbB2-driven breast cancer models

Por Desale, Swapnil S., Raja, Srikumar M., Kim, Jong Oh, Mohapatra, Bhopal, Soni, Kruti S., Luan, Haitao, Williams, Stetson H., Bielecki, Tim A, Feng, Dan, Storck, Matthew, Band, Vimla, Cohen, Samuel M., Band, Hamid, Bronich, Tatiana K.
Publicado no J Control Release (2015)

NF-κB protects from the lysosomal pathway of cell death

Por Liu, Ni, Raja, Srikumar M., Zazzeroni, Francesca, Metkar, Sunil S., Shah, Ramila, Zhang, Manling, Wang, Yue, Brömme, Dieter, Russin, William A., Lee, Justine C., Peter, Marcus E., Froelich, Christopher J., Franzoso, Guido, Ashton-Rickardt, Philip G.
Publicado em 2003

Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration

Por Duan, Lei, Raja, Srikumar M., Chen, Gengsheng, Virmani, Sumeet, Williams, Stetson H., Clubb, Robert J., Mukhopadhyay, Chandrani, Rainey, Mark A., Ying, Guoguang, Dimri, Manjari, Chen, Jing, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid
Publicado em 2011

Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

Por Mohapatra, Bhopal, Ahmad, Gulzar, Nadeau, Scott, Zutshi, Neha, An, Wei, Scheffe, Sarah, Dong, Lin, Feng, Dan, Goetz, Benjamin, Arya, Priyanka, Bailey, Tameka A., Palermo, Nicholas, Borgstahl, Gloria E.O., Natarajan, Amarnath, Raja, Srikumar M., Naramura, Mayumi, Band, Vimla, Band, Hamid
Publicado em 2012

Distinct Roles for Rho Versus Rac/Cdc42 GTPases Downstream of Vav2 in Regulating Mammary Epithelial Acinar Architecture

Por Duan, Lei, Chen, Gengsheng, Virmani, Sumeet, Ying, GuoGuang, Raja, Srikumar M., Chung, Byung Min, Rainey, Mark A., Dimri, Manjari, Ortega-Cava, Cesar F., Zhao, Xiangshan, Clubb, Robert J., Tu, Chun, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid
Publicado em 2010

Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program

Por Luan, Haitao, Mohapatra, Bhopal, Bielecki, Timothy A., Mushtaq, Insha, Mirza, Sameer, Jennings, Tameka A., Clubb, Robert J., An, Wei, Ahmed, Dena, Ansari, Rokaya El, Storck, Matthew D., Mishra, Nitish K., Guda, Chittibabu, Sheinin, Yuri M., Meza, Jane L., Raja, Srikumar, Rakha, Emad A., Band, Vimla, Band, Hamid
Publicado no Cancer Res (2018)