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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
Granzyme B (GrB), acting similar to an apical caspase, efficiently activates a proteolytic cascade after intracellular delivery by perforin. Studies here were designed to learn whether the physiologic effector, GrB–serglycin, initiates apoptosis primarily through caspase-3 or through BH3-only protei...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173758/ https://ncbi.nlm.nih.gov/pubmed/12629051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210158 |
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