A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathwaydependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells

ErbB2 (or Her2/Neu) overexpression in breast cancer signifies poorer prognosis, yet it has provided an avenue for targeted therapy as demonstrated by the success of humanized monoclonal antibody Trastuzumab (Herceptin™). Resistance to Trastuzumab and eventual failure in most cases, however, necessit...

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Hauptverfasser: Raja, Srikumar M., Clubb, Robert J., Bhattacharyya, Mitra, Dimri, Manjari, Cheng, Hao, Pan, Wei, Ortega-Cava, Cesar, Lakku-Reddi, Alagarsamy, Naramura, Mayumi, Band, Vimla, Band, Hamid
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727620/
https://ncbi.nlm.nih.gov/pubmed/18769124
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