Anticancer activity of celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

The receptor tyrosine kinase ErbB2 is overexpressed in up to a third of breast cancers, allowing targeted therapy with ErbB2-directed humanized antibodies such as Trastuzumab. Concurrent targeting of ErbB2 stability with HSP90 inhibitors is synergistic with Trastuzumab, suggesting that pharmacologic...

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Autores principales: Raja, Srikumar M, Clubb, Robert J, Ortega-Cava, Cesar, Williams, Stetson H, Bailey, Tameka A, Duan, Lei, Zhao, Xiangshan, Reddi, Alagarasamy L, Nyong, Abijah M, Natarajan, Amarnath, Band, Vimla, Band, Hamid
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2011
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047084/
https://ncbi.nlm.nih.gov/pubmed/21088503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.2.13959
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