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High-throughput compatible FRET based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

Deubiquitinases (DUBs) play an important role in regulating the ubiquitin landscape of proteins. The DUB AMSH (Associated Molecule with the SH3 domain of STAM) has been shown to be involved in regulating the ubiquitin-dependent downregulation of activated cell surface receptors via the endo-lysosoma...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Arnst, Jamie L., Davies, Christopher W., Raja, Srikumar M., Das, Chittaranjan, Natarajan, Amarnath
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784021/
https://ncbi.nlm.nih.gov/pubmed/23747283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2013.05.017
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