High-throughput compatible FRET based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

Deubiquitinases (DUBs) play an important role in regulating the ubiquitin landscape of proteins. The DUB AMSH (Associated Molecule with the SH3 domain of STAM) has been shown to be involved in regulating the ubiquitin-dependent downregulation of activated cell surface receptors via the endo-lysosoma...

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Bibliographic Details
Main Authors: Arnst, Jamie L., Davies, Christopher W., Raja, Srikumar M., Das, Chittaranjan, Natarajan, Amarnath
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784021/
https://ncbi.nlm.nih.gov/pubmed/23747283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2013.05.017
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