Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program

CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Using an extensive and well-annotated breast cancer tissue collection, we identified the loss of nuclear but not cytoplasmic CHIP to predict more...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Luan, Haitao, Mohapatra, Bhopal, Bielecki, Timothy A., Mushtaq, Insha, Mirza, Sameer, Jennings, Tameka A., Clubb, Robert J., An, Wei, Ahmed, Dena, Ansari, Rokaya El, Storck, Matthew D., Mishra, Nitish K., Guda, Chittibabu, Sheinin, Yuri M., Meza, Jane L., Raja, Srikumar, Rakha, Emad A., Band, Vimla, Band, Hamid
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955821/
https://ncbi.nlm.nih.gov/pubmed/29510992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2140
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