Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene

Mutations of the tyrosine kinase-directed ubiquitin ligase CBL cause myeloid leukemias, but the molecular determinants of the dominant leukemogenic activity of mutant CBL oncogenes are unclear. Here, we first define a gain-of-function attribute of the most common leukemia-associated CBL mutant, Y371...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nadeau, Scott A., An, Wei, Mohapatra, Bhopal C., Mushtaq, Insha, Bielecki, Timothy A., Luan, Haitao, Zutshi, Neha, Ahmad, Gulzar, Storck, Matthew D., Sanada, Masashi, Ogawa, Seishi, Band, Vimla, Band, Hamid
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339751/
https://ncbi.nlm.nih.gov/pubmed/28082680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772723
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