An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance

The ubiquitin ligases CBL and CBL-B are negative regulators of tyrosine kinase signaling with established roles in the immune system. However, their physiological roles in epithelial tissues are unknown. Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a tamox...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Development
Hauptverfasser: Mohapatra, Bhopal, Zutshi, Neha, An, Wei, Goetz, Benjamin, Arya, Priyanka, Bielecki, Timothy A., Mustaq, Insha, Storck, Matthew D., Meza, Jane L., Band, Vimla, Band, Hamid
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Stem Cells and Regeneration
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358102/
https://ncbi.nlm.nih.gov/pubmed/28100467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138164
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