A novel CBL-B(flox/flox) mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells

CBL-family ubiquitin ligases are critical negative regulators of tyrosine kinase signaling, with a clear redundancy between CBL and CBL-B evident in the immune cell and hematopoietic stem cell studies. Since CBL and CBL-B are negative regulators of immune cell activation, elimination of their functi...

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Vydáno v:Oncotarget
Hlavní autoři: Goetz, Benjamin, An, Wei, Mohapatra, Bhopal, Zutshi, Neha, Iseka, Fany, Storck, Matthew D., Meza, Jane, Sheinin, Yuri, Band, Vimla, Band, Hamid
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239462/
https://ncbi.nlm.nih.gov/pubmed/27276677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9812
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