Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

Cbl and Cbl-b are tyrosine kinase-directed RING finger type ubiquitin ligases (E3s) that negatively regulate cellular activation pathways. E3 activity-disrupting human Cbl mutations are associated with myeloproliferative disorders (MPD) that are reproduced in mice with Cbl RING finger mutant knock-i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: An, Wei, Nadeau, Scott A., Mohapatra, Bhopal C., Feng, Dan, Zutshi, Neha, Storck, Matthew D., Arya, Priyanka, Talmadge, James E., Meza, Jane L., Band, Vimla, Band, Hamid
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496370/
https://ncbi.nlm.nih.gov/pubmed/25871390
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