Fasudil, a clinically-safe ROCK Inhibitor, Decreases Disease Burden in a Cbl/Cbl-b Deficiency-Driven Murine Model of Myeloproliferative Disorders

OBJECTIVES: Mutations in Cbl or Cbl-b gene occur in 10% of MPD patients and are associated with poor prognosis. Hematopoietic Cbl/Cbl-b double knockout (DKO) leads to a disease in mice phenotypically similar to human MPDs. The aim of this study was to evaluate the anti-MPD activity of a clinical saf...

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Bibliografske podrobnosti
izdano v:Hematology
Main Authors: William, Basem M., An, Wei, Feng, Dan, Nadeau, Scott, Mohapatra, Bhopal C, Storck, Matthew A., Band, Vimla, Band, Hamid
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555218/
https://ncbi.nlm.nih.gov/pubmed/26177294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1607845415Y.0000000031
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