Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene

Mutations of the tyrosine kinase-directed ubiquitin ligase CBL cause myeloid leukemias, but the molecular determinants of the dominant leukemogenic activity of mutant CBL oncogenes are unclear. Here, we first define a gain-of-function attribute of the most common leukemia-associated CBL mutant, Y371...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Nadeau, Scott A., An, Wei, Mohapatra, Bhopal C., Mushtaq, Insha, Bielecki, Timothy A., Luan, Haitao, Zutshi, Neha, Ahmad, Gulzar, Storck, Matthew D., Sanada, Masashi, Ogawa, Seishi, Band, Vimla, Band, Hamid
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339751/
https://ncbi.nlm.nih.gov/pubmed/28082680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772723
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