Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis

Por Povero, Davide, Feldstein, Ariel E.
Publicado no Diabetes Metab J (2016)

Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration

Por Eguchi, Akiko, Mulya, Anny, Lazic, Milos, Radhakrishnan, Deepa, Berk, Michael P., Povero, Davide, Gornicka, Agnieszka, Feldstein, Ariel E.
Publicado no PLoS One (2015)

Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

Por Povero, Davide, Eguchi, Akiko, Li, Hongying, Johnson, Casey D., Papouchado, Bettina G., Wree, Alexander, Messer, Karen, Feldstein, Ariel E.
Publicado no PLoS One (2014)

Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet induced NASH model

Por Thapaliya, Samjhana, Wree, Alexander, Povero, Davide, Inzaugarat, Maria Eugenia, Berk, Michael, Dixon, Laura, Papouchado, Bettina G., Feldstein, Ariel E
Publicado no Dig Dis Sci (2014)

Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice

Por Lazic, Milos, Eguchi, Akiko, Berk, Michael P., Povero, Davide, Papouchado, Bettina, Mulya, Anny, Johnson, Casey D., Feldstein, Ariel E.
Publicado no J Hepatol (2014)

ARGINASE 2 DEFICIENCY RESULTS IN SPONTANEOUS STEATOHEPATITIS: A NOVEL LINK BETWEEN INNATE IMMUNE ACTIVATION AND HEPATIC DE NOVO LIPOGENESIS

Por Navarro, Laura A., Wree, Alexander, Povero, Davide, Berk, Michael P., Eguchi, Akiko, Ghosh, Sudakshina, Papouchado, Bettina G., Erzurum, Serpil C., Feldstein, Ariel E.
Publicado no J Hepatol (2014)

Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis

Por Eguchi, Akiko, Yoshitomi, Toru, Lazic, Milos, Johnson, Casey D, Vong, Long Binh, Wree, Alexander, Povero, Davide, Papouchado, Bettina G, Nagasaki, Yukio, Feldstein, Ariel E
Publicado no Nanomedicine (Lond) (2015)

Emricasan, a pan caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation

Por Eguchi, Akiko, Koyama, Yukinori, Wree, Alexander, Johnson, Casey D., Nakamura, Ryota, Povero, Davide, Kneiber, David, Tameda, Masahiko, Contreras, Patricia, Spada, Al, Feldstein, Ariel E.
Publicado no J Mol Med (Berl) (2018)

Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

Por Lazic, Milos, Inzaugarat, Maria Eugenia, Povero, Davide, Zhao, Iris C., Chen, Mark, Nalbandian, Madlena, Miller, Yury I., Cherñavsky, Alejandra C., Feldstein, Ariel E., Sears, Dorothy D.
Publicado em 2014

Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor-γ

Por Povero, Davide, Panera, Nadia, Eguchi, Akiko, Johnson, Casey D., Papouchado, Bettina G., de Araujo Horcel, Lucas, Pinatel, Eva M., Alisi, Anna, Nobili, Valerio, Feldstein, Ariel E.
Publicado no Cell Mol Gastroenterol Hepatol (2015)

Extracellular vesicles released by hepatocytes from gastric infusion model of ALD contain a miRNA barcode that can be detected in blood

Por Eguchi, Akiko, Lazaro, Raul G, Wang, Jiaohong, Kim, Jihoon, Povero, Davide, Willliams, Brandon, Ho, Samuel B, Stärkel, Peter, Schnabl, Bernd, Ohno-Machado, Lucila, Tsukamoto, Hidekazu, Feldstein, Ariel E.
Publicado no Hepatology (2016)

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells

Por Povero, Davide, Eguchi, Akiko, Niesman, Ingrid R., Andronikou, Nektaria, de Mollerat du Jeu, Xavier, Mulya, Anny, Berk, Michael, Lazic, Milos, Thapaliya, Samjana, Parola, Maurizio, Patel, Hemal H., Feldstein, Ariel E.
Publicado em 2013

Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis

Por Povero, Davide, Pinatel, Eva M., Leszczynska, Aleksandra, Goyal, Nidhi P., Nishio, Takahiro, Kim, Jihoon, Kneiber, David, de Araujo Horcel, Lucas, Eguchi, Akiko, Ordonez, Paulina M., Kisseleva, Tatiana, Feldstein, Ariel E.
Publicado no JCI Insight (2019)

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Por Cabrera, Daniel, Wree, Alexander, Povero, Davide, Solís, Nancy, Hernandez, Alejandra, Pizarro, Margarita, Moshage, Han, Torres, Javiera, Feldstein, Ariel E., Cabello-Verrugio, Claudio, Brandan, Enrique, Barrera, Francisco, Arab, Juan Pablo, Arrese, Marco
Publicado no Sci Rep (2017)

Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH

Por Povero, Davide, Yamashita, Hirokazu, Ren, Wenhua, Subramanian, Mani G., Myers, Robert P., Eguchi, Akiko, Simonetto, Douglas A., Goodman, Zachary D., Harrison, Stephen A., Sanyal, Arun J., Bosch, Jaime, Feldstein, Ariel E.
Publicado no Hepatol Commun (2020)

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis

Por Cannito, Stefania, Morello, Elisabetta, Bocca, Claudia, Foglia, Beatrice, Benetti, Elisa, Novo, Erica, Chiazza, Fausto, Rogazzo, Mara, Fantozzi, Roberto, Povero, Davide, Sutti, Salvatore, Bugianesi, Elisabetta, Feldstein, Ariel E., Albano, Emanuele, Collino, Massimo, Parola, Maurizio
Publicado no PLoS One (2017)

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

Por Gaul, Susanne, Leszczynska, Aleksandra, Alegre, Fernando, Kaufmann, Benedikt, Johnson, Casey D., Adams, Leon A., Wree, Alexander, Damm, Georg, Seehofer, Daniel, Calvente, Carolina J., Povero, Davide, Kisseleva, Tatiana, Eguchi, Akiko, McGeough, Matthew D., Hoffman, Hal M., Pelegrin, Pablo, Laufs, Ulrich, Feldstein, Ariel E.
Publicado no J Hepatol (2020)