Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

Obesity is associated with metabolic perturbations including liver and adipose tissue inflammation, insulin resistance, and type 2 diabetes. Omega-6 fatty acids (ω6) promote and omega-3 fatty acids (ω3) reduce inflammation as they can be metabolized to pro- and anti-inflammatory eicosanoids, respect...

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Main Authors: Lazic, Milos, Inzaugarat, Maria Eugenia, Povero, Davide, Zhao, Iris C., Chen, Mark, Nalbandian, Madlena, Miller, Yury I., Cherñavsky, Alejandra C., Feldstein, Ariel E., Sears, Dorothy D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175074/
https://ncbi.nlm.nih.gov/pubmed/25251155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107658
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