Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet induced NASH model

BACKGROUND/AIMS: Hepatocyte cell death is a key feature of nonalcoholic steohepatitis (NASH). As the contribution of specific caspases remains unclear, our aim was to ascertain the effect of caspase 3 suppression on liver injury and fibrogenesis. METHODS: C57BL/6 wild-type (WT), and caspase 3 knock...

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Detalhes bibliográficos
Publicado no:Dig Dis Sci
Main Authors: Thapaliya, Samjhana, Wree, Alexander, Povero, Davide, Inzaugarat, Maria Eugenia, Berk, Michael, Dixon, Laura, Papouchado, Bettina G., Feldstein, Ariel E
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512760/
https://ncbi.nlm.nih.gov/pubmed/24795036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-014-3167-6
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