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Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis.

Nonalcoholic steatohepatitis (NASH) is associated with caspase activation. However, a role for pro-inflammatory caspases or inflammasomes has not been explored in diet-induced liver injury. Our aims were to examine the role of caspase-1 in high fat-induced NASH. C57BL/6 wild-type and caspase 1-knock...

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Main Authors: Laura J Dixon, Chris A Flask, Bettina G Papouchado, Ariel E Feldstein, Laura E Nagy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2013-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3567081?pdf=render
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