Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development

Por Delire, Bénédicte, Stärkel, Peter, Leclercq, Isabelle
Publicado no J Clin Transl Hepatol (2015)

Expression and DNA-Binding Activity of Signal Transducer and Activator of Transcription 3 in Alcoholic Cirrhosis Compared to Normal Liver and Primary Biliary Cirrhosis in Humans

Por Stärkel, Peter, Bishop, Kate, Horsmans, Yves, Strain, Alastair J.
Publicado em 2003

A dysbiotic subpopulation of alcohol-dependent subjects

Por de Timary, Philippe, Leclercq, Sophie, Stärkel, Peter, Delzenne, Nathalie
Publicado no Gut Microbes (2016)

Dysbiosis-induced intestinal inflammation activates TNFRI and mediates alcoholic liver disease in mice

Por Chen, Peng, Stärkel, Peter, Turner, Jerrold R., Ho, Samuel B., Schnabl, Bernd
Publicado no Hepatology (2015)

Disrupted NF-κB activation after partial hepatectomy does not impair hepatocyte proliferation in rats

Por Laurent, Stéphanie, Horsmans, Yves, Stärkel, Peter, Leclercq, Isabelle, Sempoux, Christine, Lambotte, Luc
Publicado no World J Gastroenterol (2005)

Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

Por Charette, Nicolas, De Saeger, Christine, Lannoy, Valérie, Horsmans, Yves, Leclercq, Isabelle, Stärkel, Peter
Publicado em 2010

Enteric Dysbiosis Associated with a Mouse Model of Alcoholic Liver Disease

Por Yan, Arthur W., Fouts, Derrick E., Brandl, Johannes, Starkel, Peter, Torralba, Manolito, Schott, Eckart, Tsukamoto, Hide, Nelson, Karen E., Brenner, David A., Schnabl, Bernd
Publicado em 2010

The Loss of Metabolic Control on Alcohol Drinking in Heavy Drinking Alcohol-Dependent Subjects

Por de Timary, Philippe, Cani, Patrice D., Duchemin, Julie, Neyrinck, Audrey M., Gihousse, Dominique, Laterre, Pierre-François, Badaoui, Abdenor, Leclercq, Sophie, Delzenne, Nathalie M., Stärkel, Peter
Publicado em 2012

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma

Por Heindryckx, Femke, Mertens, Koen, Charette, Nicolas, Vandeghinste, Bert, Casteleyn, Christophe, Van Steenkiste, Christophe, Slaets, Dominique, Libbrecht, Louis, Staelens, Steven, Starkel, Peter, Geerts, Anja, Colle, Isabelle, Van Vlierberghe, Hans
Publicado em 2010

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

Por Hartmann, Phillipp, Chen, Peng, Wang, Hui J., Wang, Lirui, McCole, Declan F., Brandl, Katharina, Stärkel, Peter, Belzer, Clara, Hellerbrand, Claus, Tsukamoto, Hidekazu, Ho, Samuel B., Schnabl, Bernd
Publicado em 2013

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

Por Leclercq, Sophie, Matamoros, Sébastien, Cani, Patrice D., Neyrinck, Audrey M., Jamar, François, Stärkel, Peter, Windey, Karen, Tremaroli, Valentina, Bäckhed, Fredrik, Verbeke, Kristin, de Timary, Philippe, Delzenne, Nathalie M.
Publicado em 2014

Extracellular vesicles released by hepatocytes from gastric infusion model of ALD contain a miRNA barcode that can be detected in blood

Por Eguchi, Akiko, Lazaro, Raul G, Wang, Jiaohong, Kim, Jihoon, Povero, Davide, Willliams, Brandon, Ho, Samuel B, Stärkel, Peter, Schnabl, Bernd, Ohno-Machado, Lucila, Tsukamoto, Hidekazu, Feldstein, Ariel E.
Publicado no Hepatology (2016)

Intestinal REG3 Lectins Protect Against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Por Wang, Lirui, Fouts, Derrick E., Stärkel, Peter, Hartmann, Phillipp, Chen, Peng, Llorente, Cristina, DePew, Jessica, Moncera, Kelvin, Ho, Samuel B., Brenner, David A., Hooper, Lora V., Schnabl, Bernd
Publicado no Cell Host Microbe (2016)

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat

Por Fang, Meng, Dewaele, Sylviane, Zhao, Yun-peng, Stärkel, Peter, Vanhooren, Valerie, Chen, Yue-ming, Ji, Xin, Luo, Ming, Sun, Bao-mu, Horsmans, Yves, Dell, Anne, Haslam, Stuart M, Grassi, Paola, Libert, Claude, Gao, Chun-fang, Chen, Cuiying Chitty
Publicado em 2010

Sofosbuvir in Combination with Simeprevir +/- Ribavirin in Genotype 4 Hepatitis C Patients with Advanced Fibrosis or Cirrhosis: A Real-World Experience from Belgium

Por Degré, Delphine, Sersté, Thomas, Lasser, Luc, Delwaide, Jean, Starkel, Peter, Laleman, Wim, Langlet, Philippe, Reynaert, Hendrik, Bourgeois, Stefan, Vanwolleghem, Thomas, Negrin Dastis, Sergio, Gustot, Thierry, Geerts, Anja, Van Steenkiste, Christophe, de Galocsy, Chantal, Lepida, Antonia, Orlent, Hans, Moreno, Christophe
Publicado no PLoS One (2017)

Supplementation of Saturated Long-chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

Por Chen, Peng, Torralba, Manolito, Tan, Justin, Embree, Mallory, Zengler, Karsten, Stärkel, Peter, van Pijkeren, Jan-Peter, DePew, Jessica, Loomba, Rohit, Ho, Samuel B., Bajaj, Jasmohan S., Mutlu, Ece A., Keshavarzian, Ali, Tsukamoto, Hidekazu, Nelson, Karen E., Fouts, Derrick E., Schnabl, Bernd
Publicado no Gastroenterology (2014)

Digoxin Suppresses Pyruvate Kinase M2 Promoted HIF-1α Transactivation in Steatohepatitis

Por Ouyang, Xinshou, Han, Sheng-Na, Zhang, Ji-Yuan, Nemeth, Balazs Tamas, Pacher, Pal, Feng, Dechun, Bataller, Ramon, Cabezas, Joaquin, Stärkel, Peter, Caballeria, Joan, Pongratz, Rebecca LePine, Cai, Shi-Ying, Schnabl, Bernd, Hoque, Rafaz, Chen, Yonglin, Yang, Wei-hong, Martinez, Irma Garcia, Wang, Fu-Sheng, Gao, Bin, Torok, Natalie Julia, Kibbey, Richard Glenn, Mehal, Wajahat Zafar
Publicado no Cell Metab (2018)

Intestinal fungi contribute to development of alcoholic liver disease

Por Yang, An-Ming, Inamine, Tatsuo, Hochrath, Katrin, Chen, Peng, Wang, Lirui, Llorente, Cristina, Bluemel, Sena, Hartmann, Phillipp, Xu, Jun, Koyama, Yukinori, Kisseleva, Tatiana, Torralba, Manolito G., Moncera, Kelvin, Beeri, Karen, Chen, Chien-Sheng, Freese, Kim, Hellerbrand, Claus, Lee, Serene M.L., Hoffman, Hal M., Mehal, Wajahat Z., Garcia-Tsao, Guadalupe, Mutlu, Ece A., Keshavarzian, Ali, Brown, Gordon D., Ho, Samuel B., Bataller, Ramon, Stärkel, Peter, Fouts, Derrick E., Schnabl, Bernd
Publicado no J Clin Invest (2017)