Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

BACKGROUND &AIMS: Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. The role of hepatocyte pyroptosis and extracellular inflammasome release in liver disease is unknown. METHODS: We used primary mouse and human hepatocytes, hepatocyte-specific L351P Nlr...

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Pubblicato in:J Hepatol
Autori principali: Gaul, Susanne, Leszczynska, Aleksandra, Alegre, Fernando, Kaufmann, Benedikt, Johnson, Casey D., Adams, Leon A., Wree, Alexander, Damm, Georg, Seehofer, Daniel, Calvente, Carolina J., Povero, Davide, Kisseleva, Tatiana, Eguchi, Akiko, McGeough, Matthew D., Hoffman, Hal M., Pelegrin, Pablo, Laufs, Ulrich, Feldstein, Ariel E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749849/
https://ncbi.nlm.nih.gov/pubmed/32763266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.07.041
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