NLRP3 inflammasome driven liver injury and fibrosis: roles of IL- 17 and TNF

The NLRP3 inflammasome, a caspase-1 activation platform plays a key role in the modulation of liver inflammation and fibrosis. Here, we tested the hypothesis that interleukin 17 (IL-17) and tumor necrosis factor (TNF) are key cytokines involved in amplifying and perpetuating the liver damage and fib...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Wree, Alexander, McGeough, Matthew D., Inzaugarat, Maria Eugenia, Eguchi, Akiko, Schuster, Susanne, Johnson, Casey D., Peña, Carla A., Geisler, Lukas J., Papouchado, Bettina G, Hoffman, Hal M., Feldstein, Ariel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849484/
https://ncbi.nlm.nih.gov/pubmed/28902427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29523
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