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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis

Inflammasome activation has been recently recognized to play a central role in the development of drug-induced and obesity-associated liver disease. However, the sources and mechanisms of inflammasome mediated liver damage remain poorly understood. Our aim was to investigate the effect of NLRP3 infl...

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Detalhes bibliográficos
Main Authors: Wree, Alexander, Eguchi, Akiko, McGeough, Matthew D., Pena, Carla A., Johnson, Casey D., Canbay, Ali, Hoffman, Hal M., Feldstein, Ariel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008151/
https://ncbi.nlm.nih.gov/pubmed/23813842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26592
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