NLRP3 inflammasome activation is required for fibrosis development in NAFLD

NLR inflammasomes, caspase 1 activation platforms critical for processing key pro-inflammatory cytokines, have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). As the direct role of the NLRP3 inflammasome remains unclear, we tested effects of persistent NLRP3 activatio...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Wree, Alexander, McGeough, Matthew D., Peña, Carla A., Schlattjan, Martin, Li, Hongying, Inzaugarat, Maria Eugenia, Messer, Karen, Canbay, Ali, Hoffman, Hal M., Feldstein, Ariel E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349416/
https://ncbi.nlm.nih.gov/pubmed/24861026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-014-1170-1
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