The Structure-Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious

Por Popowicz, Grzegorz M., Dömling, Alexander, Holak, Tad A.
Publicado em 2011

The p53-MDM2/MDMX axis – A chemotype perspective

Por Khoury, Kareem, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander
Publicado em 2011

Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe

Por Guo, Shaohua, Popowicz, Grzegorz Maria, Li, Daoming, Yuan, Dongjuan, Wang, Yonghua
Publicado no FEBS Open Bio (2016)

Paramagnetic NMR in drug discovery

Por Softley, Charlotte A., Bostock, Mark J., Popowicz, Grzegorz M., Sattler, Michael
Publicado no J Biomol NMR (2020)

Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins

Por Sitar, Tomasz, Popowicz, Grzegorz M., Siwanowicz, Igor, Huber, Robert, Holak, Tad A.
Publicado em 2006

Structures of the Arm-type Binding Domains of HPI and HAI7 Integrases

Por Szwagierczak, Aleksandra, Antonenka, Uladzimir, Popowicz, Grzegorz M., Sitar, Tomasz, Holak, Tad A., Rakin, Alexander
Publicado em 2009

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

Por Ammon, Tim, Mishra, Shravan Kumar, Kowalska, Kaja, Popowicz, Grzegorz M., Holak, Tad A., Jentsch, Stefan
Publicado em 2014

Inhibitors of glycosomal protein import provide new leads against trypanosomiasis

Por Kalel, Vishal C., Emmanouilidis, Leonidas, Dawidowski, Maciej, Schliebs, Wolfgang, Sattler, Michael, Popowicz, Grzegorz M., Erdmann, Ralf
Publicado no Microb Cell (2017)

Exhaustive Fluorine Scanning towards Potent p53-Mdm2 Antagonists

Por Huang, Yijun, Wolf, Siglinde, Koes, David, Popowicz, Grzegorz M., Camacho, Carlos J., Holak, Tad A., Dömling, Alexander
Publicado em 2011

Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1)

Por Zak, Krzysztof M., Kalińska, Magdalena, Wątor, Elżbieta, Kuśka, Katarzyna, Krutyhołowa, Rościsław, Dubin, Grzegorz, Popowicz, Grzegorz M., Grudnik, Przemysław
Publicado no Int J Mol Sci (2019)

Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53-Hdm2 Antagonists

Por Czarna, Anna, Beck, Barbara, Srivastava, Stuti, Popowicz, Grzegorz, Wolf, Siglinde, Huang, Yijun, Bista, Michal, Holak, Tad A., Dömling, Alexander
Publicado em 2010

Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

Por Mishra, Shravan Kumar, Ammon, Tim, Popowicz, Grzegorz M., Krajewski, Marcin, Nagel, Roland J., Ares, Manuel, Holak, Tad A., Jentsch, Stefan
Publicado em 2011

Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

Por Bista, Michal, Wolf, Siglinde, Khoury, Kareem, Kowalska, Kaja, Huang, Yijun, Wrona, Ewa, Arciniega, Marcelino, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander
Publicado em 2013

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation

Por Ducka, Anna M., Joel, Peteranne, Popowicz, Grzegorz M., Trybus, Kathleen M., Schleicher, Michael, Noegel, Angelika A., Huber, Robert, Holak, Tad A., Sitar, Tomasz
Publicado em 2010

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Por Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J.
Publicado em 2012

Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus

Por Burchacka, Ewa, Zdzalik, Michal, Niemczyk, Justyna-Stec, Pustelny, Katarzyna, Popowicz, Grzegorz, Wladyka, Benedykt, Dubin, Adam, Potempa, Jan, Sienczyk, Marcin, Dubin, Grzegorz, Oleksyszyn, Jozef
Publicado em 2014

The Photocatalyzed Thiol‐ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins

Por Denis, Maxime, Softley, Charlotte, Giuntini, Stefano, Gentili, Matteo, Ravera, Enrico, Parigi, Giacomo, Fragai, Marco, Popowicz, Grzegorz, Sattler, Michael, Luchinat, Claudio, Cerofolini, Linda, Nativi, Cristina
Publicado no Chemphyschem (2020)

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

Por Huang, Yijun, Wolf, Siglinde, Beck, Barbara, Köhler, Lisa-Maria, Khoury, Kareem, Popowicz, Grzegorz M., Goda, Sayed K, Subklewe, Marion, Twarda, Aleksandra, Holak, Tad A., Dömling, Alexander
Publicado em 2014

Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase

Por Softley, Charlotte A., Zak, Krzysztof M., Bostock, Mark J., Fino, Roberto, Zhou, Richard Xu, Kolonko, Marta, Mejdi-Nitiu, Ramona, Meyer, Hannelore, Sattler, Michael, Popowicz, Grzegorz M.
Publicado no Antimicrob Agents Chemother (2020)

Correction for Softley et al., “Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase”

Por Softley, Charlotte A., Zak, Krzysztof M., Bostock, Mark J., Fino, Roberto, Zhou, Richard Xu, Kolonko, Marta, Mejdi-Nitiu, Ramona, Meyer, Hannelore, Sattler, Michael, Popowicz, Grzegorz M.
Publicado no Antimicrob Agents Chemother (2020)