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The p53-MDM2/MDMX axis – A chemotype perspective

The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 consists of the most intense studied PPI with a group of small molecular weight antagonists described and many more disclosed in patent literature. Due to the Å-level structural insight into p53 interac...

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Détails bibliographiques
Auteurs principaux: Khoury, Kareem, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898590/
https://ncbi.nlm.nih.gov/pubmed/24466404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C0MD00248H
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