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The p53-MDM2/MDMX axis – A chemotype perspective
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 consists of the most intense studied PPI with a group of small molecular weight antagonists described and many more disclosed in patent literature. Due to the Å-level structural insight into p53 interac...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898590/ https://ncbi.nlm.nih.gov/pubmed/24466404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C0MD00248H |
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