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The Structure-Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious
The p53 protein is the cell’s principal bastion of defense against tumor-associated DNA damage. Commonly referred as a “guardian of the genome”, p53 is responsible for determining the fate of the cell when the integrity of its genome is damaged. The development of tumors requires breaching this defe...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113661/ https://ncbi.nlm.nih.gov/pubmed/21341346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201003863 |
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