Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

Reactivation of p53 by release of the functional protein from its inhibition by MDM2 provides an efficient, nongenotoxic approach to a wide variety of cancers. We present the cocrystal structures of two complexes of MDM2 with inhibitors based on 6-chloroindole scaffolds. Both molecules bound to a di...

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Bibliografiske detaljer
Main Authors: Bista, Michal, Wolf, Siglinde, Khoury, Kareem, Kowalska, Kaja, Huang, Yijun, Wrona, Ewa, Arciniega, Marcelino, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104591/
https://ncbi.nlm.nih.gov/pubmed/24207125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.006
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