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Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction
Reactivation of p53 by release of the functional protein from its inhibition by MDM2 provides an efficient, nongenotoxic approach to a wide variety of cancers. We present the cocrystal structures of two complexes of MDM2 with inhibitors based on 6-chloroindole scaffolds. Both molecules bound to a di...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104591/ https://ncbi.nlm.nih.gov/pubmed/24207125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.006 |
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