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1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity
1,4-Thienodiazepine-2,5-diones have been synthesized via the Ugi-Deprotection-Cyclization (UDC) approach starting from Gewald 2-aminothiophenes i n a convergent and versatile manner. The resulting scaffold is unprecedented, cyclic and peptidomimetic with four points of diversity introduced from read...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913441/ https://ncbi.nlm.nih.gov/pubmed/20492448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00989.x |
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