1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity

1,4-Thienodiazepine-2,5-diones have been synthesized via the Ugi-Deprotection-Cyclization (UDC) approach starting from Gewald 2-aminothiophenes i n a convergent and versatile manner. The resulting scaffold is unprecedented, cyclic and peptidomimetic with four points of diversity introduced from read...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Yijun, Wolf, Siglinde, Bista, Michal, Meireles, Lidio, Camacho, Carlos, Holak, Tad A., Dömling, Alexander
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913441/
https://ncbi.nlm.nih.gov/pubmed/20492448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00989.x
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