Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

[Image: see text] The inhibition of p53-MDM2 interaction is a promising new approach to non-genotoxic cancer treatment. A potential application for drugs blocking the p53-MDM2 interaction is acute myeloid leukemia (AML) due to the occurrence of wild type p53 (wt p53) in the majority of patients. Alt...

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Bibliographic Details
Main Authors: Huang, Yijun, Wolf, Siglinde, Beck, Barbara, Köhler, Lisa-Maria, Khoury, Kareem, Popowicz, Grzegorz M., Goda, Sayed K, Subklewe, Marion, Twarda, Aleksandra, Holak, Tad A., Dömling, Alexander
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985958/
https://ncbi.nlm.nih.gov/pubmed/24405416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400728e
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