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Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists
Although there is no shortage of potential drug targets, there are only a handful known low-molecular-weight inhibitors of protein-protein interactions (PPIs). One problem is that current efforts are dominated by low-yield high-throughput screening, whose rigid framework is not suitable for the dive...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299697/ https://ncbi.nlm.nih.gov/pubmed/22427896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032839 |
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