Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Although there is no shortage of potential drug targets, there are only a handful known low-molecular-weight inhibitors of protein-protein interactions (PPIs). One problem is that current efforts are dominated by low-yield high-throughput screening, whose rigid framework is not suitable for the dive...

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Autori principali: Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299697/
https://ncbi.nlm.nih.gov/pubmed/22427896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032839
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