Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

Por Peng, Lee F., Stanton, Benjamin Z., Maloof, Nicole, Wang, Xiang, Schreiber, Stuart L.
Publicado em 2009

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

Por Tai, Andrew W., Benita, Yair, Peng, Lee F., Kim, Sun-Suk, Sakamoto, Naoya, Xavier, Ramnik J., Chung, Raymond T.
Publicado em 2009

Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus

Por Rodgers, Mary A, Villareal, Valerie A, Schaefer, Esperance A, Peng, Lee F, Corey, Kathleen E, Chung, Raymond T, Yang, Priscilla L
Publicado em 2012

Suppressor of Cytokine Signaling 3 Suppresses Hepatitis C Virus Replication in an mTOR-Dependent Manner

Por Shao, Run-Xuan, Zhang, Leiliang, Peng, Lee F., Sun, Eileen, Chung, Woo Jin, Jang, Jae Yong, Tsai, Wei-Lun, Hyppolite, Guibenson, Chung, Raymond T.
Publicado em 2010

IL28B inhibits Hepatitis C virus replication through the JAK-STAT pathway

Por Zhang, Leiliang, Jilg, Nikolaus, Shao, Run-Xuan, Lin, Wenyu, Fusco, Dahlene N., Zhao, Hong, Goto, Kaku, Peng, Lee F., Chen, Wen-Chi, Chung, Raymond T.
Publicado em 2010

SOCS1 Abrogates IFN’s Antiviral Effect on Hepatitis C Virus Replication

Por Shao, Run-Xuan, Zhang, Leiliang, Hong, Zhi, Goto, Kaku, Cheng, Du, Chen, Wen-Chi, Jilg, Nikolaus, Kumthip, Kattareeya, Fusco, Dahlene N., Peng, Lee F., Chung, Raymond T.
Publicado em 2012

The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling

Por Goto, Kaku, Lin, Wenyu, Zhang, Leiliang, Jilg, Nikolaus, Shao, Run-Xuan, Schaefer, Esperance A.K., Zhao, Hong, Fusco, Dahlene N., Peng, Lee F., Kato, Naoya, Chung, Raymond T.
Publicado em 2013

The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing

Por Lin, Wenyu, Zhu, Chuanlong, Hong, Jian, Zhao, Lei, Jilg, Nikolaus, Fusco, Dahlene N., Schaefer, Esperance A., Brisac, Cynthia, Liu, Xiao, Peng, Lee F., Xu, Qikai, Chung, Raymond T.
Publicado no J Hepatol (2014)

HCV regulates TGF-β1 production through the generation of reactive oxygen species in an NFκB-dependent manner

Por Lin, Wenyu, Tsai, Wei-Lun, Shao, Run-Xuan, Wu, Guoyang, Peng, Lee F., Barlow, Lydia L., Chung, Woo Jin, Zhang, Leiliang, Zhao, Hong, Jang, Jae-Young, Chung, Raymond T.
Publicado em 2010

HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

Por Chusri, Pattranuch, Kumthip, Kattareeya, Hong, Jian, Zhu, Chuanlong, Duan, Xiaoqiong, Jilg, Nikolaus, Fusco, Dahlene N., Brisac, Cynthia, Schaefer, Esperance A., Cai, Dachuan, Peng, Lee F., Maneekarn, Niwat, Lin, Wenyu, Chung, Raymond T.
Publicado no Sci Rep (2016)

Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C

Por Schaefer, Esperance A K, Meixiong, James, Mark, Christina, Deik, Amy, Motola, Daniel L, Fusco, Dahlene, Yang, Andrew, Brisac, Cynthia, Salloum, Shadi, Lin, Wenyu, Clish, Clary B, Peng, Lee F, Chung, Raymond T
Publicado no World J Gastroenterol (2016)

A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus

Por Zhao, Hong, Lin, Wenyu, Kumthip, Kattareeya, Cheng, Du, Fusco, Dahlene N, Hofmann, Oliver, Jilg, Nikolaus, Tai, Andrew W., Goto, Kaku, Zhang, Leiliang, Hide, Winston, Jang, Jae Young, Peng, Lee F, Chung, Raymond T
Publicado em 2011

HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB

Por Lin, Wenyu, Wu, Guoyang, Li, Shaoyong, Weinberg, Ethan M., Kumthip, Kattareeya, Peng, Lee F., Méndez-Navarro, Jorge, Chen, Wen-Chi, Jilg, Nikolaus, Zhao, Hong, Goto, Kaku, Zhang, Leiliang, Brockman, Mark A., Schuppan, Detlef, Chung, Raymond T.
Publicado em 2011

HIV increases HCV-induced hepatocyte apoptosis

Por Jang, Jae Young, Shao, Run-Xuan, Lin, Wenyu, Weinberg, Ethan, Chung, Woo Jin, Tsai, Wei Lun, Zhao, Hong, Goto, Kaku, Zhang, Leiliang, Mendez-Navarro, Jorge, Jilg, Nikolaus, Peng, Lee F., Brockman, Mark A., Chung, Raymond T.
Publicado em 2010

Ceestatin, a Novel Small Molecule Inhibitor of Hepatitis C Virus Replication, Inhibits 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase

Por Peng, Lee F., Schaefer, Esperance A. K., Maloof, Nicole, Skaff, Andrew, Berical, Andrew, Belon, Craig A., Heck, Julie A., Lin, Wenyu, Frick, David N., Allen, Todd M., Miziorko, Henry M., Schreiber, Stuart L., Chung, Raymond T.
Publicado em 2011

Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen

Por Peng , Lee F., Kim, Sun Suk, Matchacheep, Sirinya, Lei, Xiaoguang, Su, Shun, Lin, Wenyu, Runguphan, Weerawat, Choe, Won-Hyeok, Sakamoto, Naoya, Ikeda, Masanori, Kato, Nobuyuki, Beeler, Aaron B., Porco, John A., Schreiber, Stuart L., Chung, Raymond T.
Publicado em 2007

EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway

Por Zhu, Chuanlong, Xiao, Fei, Hong, Jian, Wang, Kun, Liu, Xiao, Cai, Dachuan, Fusco, Dahlene N., Zhao, Lei, Jeong, Soung Won, Brisac, Cynthia, Chusri, Pattranuch, Schaefer, Esperance A., Zhao, Hong, Peng, Lee F., Lin, Wenyu, Chung, Raymond T.
Publicado no J Virol (2015)

Hepatitis C Virus NS5A Disrupts STAT1 Phosphorylation and Suppresses Type I Interferon Signaling

Por Kumthip, Kattareeya, Chusri, Pattranuch, Jilg, Nikolaus, Zhao, Lei, Fusco, Dahlene N., Zhao, Hong, Goto, Kaku, Cheng, Du, Schaefer, Esperance A., Zhang, Leiliang, Pantip, Chansom, Thongsawat, Satawat, O'Brien, Amornrat, Peng, Lee F., Maneekarn, Niwat, Chung, Raymond T., Lin, Wenyu
Publicado em 2012

Kinetic Differences in the Induction of Interferon Stimulated Genes by Interferon-α and IL28B are altered by Infection with Hepatitis C Virus

Por Jilg, Nikolaus, Lin, Wenyu, Hong, Jian, Schaefer, Esperance A., Wolski, David, Meixong, James, Goto, Kaku, Brisac, Cynthia, Chusri, Pattranuch, Fusco, Dahlene N., Chevaliez, Stephane, Luther, Jay, Kumthip, Kattareeya, Urban, Thomas J., Peng, Lee F., Lauer, Georg M., Chung, Raymond T.
Publicado em 2014

A small molecule that binds Hedgehog and blocks its signaling in human cells

Por Stanton, Benjamin Z., Peng, Lee F., Maloof, Nicole, Nakai, Kazuo, Wang, Xiang, Herlihy, Kara M., Duffner, Jay L., Taveras, Kennedy M., Hyman, Joel M., Lee, Sam W., Koehler, Angela N., Chen, James K., Fox, Julia L., Mandinova, Anna, Schreiber, Stuart L.
Publicado em 2009