Hepatitis C Virus NS5A Disrupts STAT1 Phosphorylation and Suppresses Type I Interferon Signaling

Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently respond better to IFN treatment than do patients infect...

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Detalhes bibliográficos
Main Authors: Kumthip, Kattareeya, Chusri, Pattranuch, Jilg, Nikolaus, Zhao, Lei, Fusco, Dahlene N., Zhao, Hong, Goto, Kaku, Cheng, Du, Schaefer, Esperance A., Zhang, Leiliang, Pantip, Chansom, Thongsawat, Satawat, O'Brien, Amornrat, Peng, Lee F., Maneekarn, Niwat, Chung, Raymond T., Lin, Wenyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421739/
https://ncbi.nlm.nih.gov/pubmed/22674974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00533-12
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