HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and PERK. HCV increases TGF-β1 and oxidative stress, which play important roles i...

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Publicado no:Sci Rep
Main Authors: Chusri, Pattranuch, Kumthip, Kattareeya, Hong, Jian, Zhu, Chuanlong, Duan, Xiaoqiong, Jilg, Nikolaus, Fusco, Dahlene N., Brisac, Cynthia, Schaefer, Esperance A., Cai, Dachuan, Peng, Lee F., Maneekarn, Niwat, Lin, Wenyu, Chung, Raymond T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772380/
https://ncbi.nlm.nih.gov/pubmed/26927933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22487
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