A small molecule that binds Hedgehog and blocks its signaling in human cells

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proved to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stanton, Benjamin Z., Peng, Lee F., Maloof, Nicole, Nakai, Kazuo, Wang, Xiang, Herlihy, Kara M., Duffner, Jay L., Taveras, Kennedy M., Hyman, Joel M., Lee, Sam W., Koehler, Angela N., Chen, James K., Fox, Julia L., Mandinova, Anna, Schreiber, Stuart L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770933/
https://ncbi.nlm.nih.gov/pubmed/19151731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.142
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