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A small molecule that binds Hedgehog and blocks its signaling in human cells
Small-molecule inhibition of extracellular proteins that activate membrane receptors has proved to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein a...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770933/ https://ncbi.nlm.nih.gov/pubmed/19151731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.142 |
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