A small molecule that binds Hedgehog and blocks its signaling in human cells

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proved to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein a...

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Main Authors: Stanton, Benjamin Z., Peng, Lee F., Maloof, Nicole, Nakai, Kazuo, Wang, Xiang, Herlihy, Kara M., Duffner, Jay L., Taveras, Kennedy M., Hyman, Joel M., Lee, Sam W., Koehler, Angela N., Chen, James K., Fox, Julia L., Mandinova, Anna, Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770933/
https://ncbi.nlm.nih.gov/pubmed/19151731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.142
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