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Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway

[Image: see text] The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which has been enabled by small-molecule probes targeting its comp...

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Main Authors: Schaefer, Giannina I., Perez, José R., Duvall, Jeremy R., Stanton, Benjamin Z., Shamji, Alykhan F., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703668/
https://ncbi.nlm.nih.gov/pubmed/23725514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400034k
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