Epigenetic regulators and their impact on therapy in acute myeloid leukemia

por Pastore, Friederike, Levine, Ross L.
Publicado en Haematologica (2016)

Impressive thrombocytosis evolving in a patient with a BCR-ABL positive CML in major molecular response during dasatinib treatment unmasks an additional JAK2V617F

por Pastore, Friederike, Schneider, Stephanie, Christ, Oliver, Hiddemann, Wolfgang, Spiekermann, Karsten
Publicado 2013

The Role of Therapeutic Leukapheresis in Hyperleukocytotic AML

por Pastore, Friederike, Pastore, Alessandro, Wittmann, Georg, Hiddemann, Wolfgang, Spiekermann, Karsten
Publicado 2014

JAK2S523L, a novel gain-of-function mutation in a critical autoregulatory residue in JAK2V617F(−) MPNs

por Pastore, Friederike, Krishnan, Aishwarya, Hammarén, Henrik M., Silvennoinen, Olli, Yan, Benedict, Levine, Ross L.
Publicado en Blood Adv (2020)

Long-term follow-up of cytogenetically normal CEBPA-mutated AML

por Pastore, Friederike, Kling, Daniela, Hoster, Eva, Dufour, Annika, Konstandin, Nikola P, Schneider, Stephanie, Sauerland, Maria C, Berdel, Wolfgang E, Buechner, Thomas, Woermann, Bernhard, Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten
Publicado 2014

Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

por Janke, Hanna, Pastore, Friederike, Schumacher, Daniela, Herold, Tobias, Hopfner, Karl-Peter, Schneider, Stephanie, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Subklewe, Marion, Bohlander, Stefan K., Hiddemann, Wolfgang, Spiekermann, Karsten, Polzer, Harald
Publicado 2014

The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML

por Pastore, Friederike, Greif, Philipp A., Schneider, Stephanie, Ksienzyk, Bianka, Mellert, Gudrun, Zellmeier, Evelyn, Braess, Jan, Sauerland, Cristina M., Heinecke, Achim, Krug, Utz, Berdel, Wolfgang E., Buechner, Thomas, Woermann, Bernhard, Hiddemann, Wolfgang, Spiekermann, Karsten
Publicado 2014

Targeting the CALR interactome in myeloproliferative neoplasms

por Pronier, Elodie, Cifani, Paolo, Merlinsky, Tiffany R., Berman, Katharine Barr, Somasundara, Amritha Varshini Hanasoge, Rampal, Raajit K., LaCava, John, Wei, Karen E., Pastore, Friederike, Maag, Jesper L.V., Park, Jane, Koche, Richard, Kentsis, Alex, Levine, Ross L.
Publicado en JCI Insight (2018)

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA

por Konstandin, Nikola P., Pastore, Friederike, Herold, Tobias, Dufour, Annika, Rothenberg-Thurley, Maja, Hinrichsen, Tanja, Ksienzyk, Bianka, Tschuri, Sebastian, Schneider, Stephanie, Hoster, Eva, Berdel, Wolfgang E., Woermann, Bernhard J., Sauerland, Maria C., Braess, Jan, Bohlander, Stefan K., Klein, Hanns-Georg, Hiddemann, Wolfgang, Metzeler, Klaus H., Spiekermann, Karsten
Publicado en Blood Adv (2018)

PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation

por Xiao, Wenbin, Bharadwaj, Maheetha, Levine, Max, Farnhoud, Noushin, Pastore, Friederike, Getta, Bartlomiej M., Hultquist, Anne, Famulare, Christopher, Medina, Juan S., Patel, Minal A., Gao, Qi, Lewis, Natasha, Pichardo, Janine, Baik, Jeeyeon, Shaffer, Brian, Giralt, Sergio, Rampal, Raajit, Devlin, Sean, Cimera, Robert, Zhang, Yanming, E. Arcila, Maria, Papaemmanuil, Elli, Levine, Ross L., Roshal, Mikhail
Publicado en Blood Adv (2018)

Combined Molecular and Clinical Prognostic Index for Relapse and Survival in Cytogenetically Normal Acute Myeloid Leukemia

por Pastore, Friederike, Dufour, Annika, Benthaus, Tobias, Metzeler, Klaus H., Maharry, Kati S., Schneider, Stephanie, Ksienzyk, Bianka, Mellert, Gudrun, Zellmeier, Evelyn, Kakadia, Purvi M., Unterhalt, Michael, Feuring-Buske, Michaela, Buske, Christian, Braess, Jan, Sauerland, Maria Cristina, Heinecke, Achim, Krug, Utz, Berdel, Wolfgang E., Buechner, Thomas, Woermann, Bernhard, Hiddemann, Wolfgang, Bohlander, Stefan K., Marcucci, Guido, Spiekermann, Karsten, Bloomfield, Clara D., Hoster, Eva
Publicado en J Clin Oncol (2014)

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

por Pastore, Friederike, Bhagwat, Neha, Pastore, Alessandro, Radzisheuskaya, Aliaksandra, Karzai, Abdul, Krishnan, Aishwarya, Li, Bing, Bowman, Robert L., Xiao, Wenbin, Viny, Aaron D., Zouak, Anouar, Park, Young C., Cordner, Keith B., Braunstein, Stephanie, Maag, Jesper L., Grego, Alexander, Mehta, Jaanvi, Wang, Min, Lin, Hong, Durham, Benjamin H., Koche, Richard P., Rampal, Raajit K., Helin, Kristian, Scherle, Peggy, Vaddi, Kris, Levine, Ross L.
Publicado en Cancer Discov (2020)

DNMT3A R882 mutations promote anthracycline resistance in acute myeloid leukemia through impaired nucleosome remodeling

por Guryanova, Olga A., Shank, Kaitlyn, Spitzer, Barbara, Luciani, Luisa, Koche, Richard P., Garrett-Bakelman, Francine E., Ganzel, Chezi, Durham, Benjamin H., Mohanty, Abhinita, Hoermann, Gregor, Rivera, Sharon A., Chramiec, Alan G., Pronier, Elodie, Bastian, Lennart, Keller, Matthew D., Tovbin, Daniel, Loizou, Evangelia, Weinstein, Abby R., Gonzalez, Adriana Rodriguez, Lieu, Yen, Rowe, Jacob M., Pastore, Friederike, McKenney, Anna Sophia, Krivtsov, Andrei V., Sperr, Wolfgang R., Cross, Justin R., Mason, Christopher E., Tallman, Martin S., Arcila, Maria E., Abdel-Wahab, Omar, Armstrong, Scott A., Kubicek, Stefan, Staber, Philipp B., Gönen, Mithat, Paietta, Elisabeth M., Melnick, Ari M., Nimer, Stephen D., Mukherjee, Siddhartha, Levine, Ross L.
Publicado en Nat Med (2016)