Ruxolitinib: a targeted treatment option for patients with polycythemia vera

بواسطة Vaddi, Kris, Verstovsek, Srdan, Kiladjian, Jean-Jacques
الحاوية / القاعدة Blood Lymphat Cancer (2016)

Myelofibrosis-associated complications: pathogenesis, clinical manifestations, and effects on outcomes

بواسطة Mughal, Tariq I, Vaddi, Kris, Sarlis, Nicholas J, Verstovsek, Srdan
منشور في 2014

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors

بواسطة Lin, Hong, Wang, Min, Zhang, Yang W., Tong, Shuilong, Leal, Raul A., Shetty, Rupa, Vaddi, Kris, Luengo, Juan I.
الحاوية / القاعدة ACS Med Chem Lett (2019)

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

بواسطة Weisberg, Stuart P., Hunter, Deborah, Huber, Reid, Lemieux, Jacob, Slaymaker, Sarah, Vaddi, Kris, Charo, Israel, Leibel, Rudolph L., Ferrante, Anthony W.
منشور في 2006

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

بواسطة Weisberg, Stuart P., Hunter, Deborah, Huber, Reid, Lemieux, Jacob, Slaymaker, Sarah, Vaddi, Kris, Charo, Israel, Leibel, Rudolph L., Ferrante, Anthony W.
منشور في 2006

Evaluating the Serial Use of the Myelofibrosis Symptom Assessment Form for Measuring Symptomatic Improvement

بواسطة Mesa, Ruben A., Kantarjian, Hagop, Tefferi, Ayalew, Dueck, Amylou, Levy, Richard, Vaddi, Kris, Erickson-Viitanen, Susan, Thomas, Deborah A., Cortes, Jorge, Borthakur, Gautam, Pardanani, Animesh D., Estrov, Zeev, Verstovsek, Srdan
منشور في 2011

Oral arsenic trioxide ORH-2014 pharmacokinetic and safety profile in patients with advanced hematologic disorders

بواسطة Ravandi, Farhad, Koumenis, Iphigenia, Johri, Anandhi, Tallman, Martin, Roboz, Gail J., Strickland, Stephen, Garcia-Manero, Guillermo, Borthakur, Gautam, Naqvi, Kiran, Meyer, Meghan, Pudipeddi, Madhu, Nidarmarthy, Sirish, Vaddi, Kris, Kantarjian, Hagop
الحاوية / القاعدة Haematologica (2020)

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

بواسطة Verstovsek, Srdan, Kantarjian, Hagop, Mesa, Ruben A., Pardanani, Animesh D., Cortes-Franco, Jorge, Thomas, Deborah A., Estrov, Zeev, Fridman, Jordan S., Bradley, Edward C., Erickson-Viitanen, Susan, Vaddi, Kris, Levy, Richard, Tefferi, Ayalew
الحاوية / القاعدة N Engl J Med (2010)

INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support

بواسطة Li, Jun, Favata, Margaret, Kelley, Jennifer A, Caulder, Eian, Thomas, Beth, Wen, Xiaoming, Sparks, Richard B, Arvanitis, Ari, Rogers, James D, Combs, Andrew P, Vaddi, Kris, Solomon, Kimberly A, Scherle, Peggy A, Newton, Robert, Fridman, Jordan S
منشور في 2010

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

بواسطة Burger, Renate, Le Gouill, Steven, Tai, Yu-Tzu, Shringarpure, Reshma, Tassone, Pierfrancesco, Neri, Paola, Podar, Klaus, Catley, Laurence, Hideshima, Teru, Chauhan, Dharminder, Caulder, Eian, Neilan, Claire L., Vaddi, Kris, Li, Jun, Gramatzki, Martin, Fridman, Jordan S., Anderson, Kenneth C.
منشور في 2009

A Multi-Institution Phase I Trial of Ruxolitinib in Patients with Chronic Myelomonocytic Leukemia (CMML)

بواسطة Padron, Eric, Dezern, Amy, Andrade-Campos, Marcio, Vaddi, Kris, Scherle, Peggy, Zhang, Qing, Ma, Yan, Balasis, Maria E., Tinsley, Sara, Ramadan, Hanadi, Zimmerman, Cassandra, Steensma, David P., Roboz, Gail J., Lancet, Jeffrey E., List, Alan F., Sekeres, Mikkael A., Komrokji, Rami S.
الحاوية / القاعدة Clin Cancer Res (2016)

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

بواسطة Koppikar, Priya, Abdel-Wahab, Omar, Hedvat, Cyrus, Marubayashi, Sachie, Patel, Jay, Goel, Aviva, Kucine, Nicole, Gardner, Jeffrey R., Combs, Andrew P., Vaddi, Kris, Haley, Patrick J., Burn, Timothy C., Rupar, Mark, Bromberg, Jacqueline F., Heaney, Mark L., de Stanchina, Elisa, Fridman, Jordan S., Levine, Ross L.
منشور في 2010

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

بواسطة Quintás-Cardama, Alfonso, Vaddi, Kris, Liu, Phillip, Manshouri, Taghi, Li, Jun, Scherle, Peggy A., Caulder, Eian, Wen, Xiaoming, Li, Yanlong, Waeltz, Paul, Rupar, Mark, Burn, Timothy, Lo, Yvonne, Kelley, Jennifer, Covington, Maryanne, Shepard, Stacey, Rodgers, James D., Haley, Patrick, Kantarjian, Hagop, Fridman, Jordan S., Verstovsek, Srdan
منشور في 2010

Validation of protein arginine methyltransferase 5 (PRMT5) as a candidate therapeutic target in the spontaneous canine model of non-Hodgkin lymphoma

بواسطة Sloan, Shelby L., Renaldo, Kyle A., Long, Mackenzie, Chung, Ji-Hyun, Courtney, Lindsay E., Shilo, Konstantin, Youssef, Youssef, Schlotter, Sarah, Brown, Fiona, Klamer, Brett G., Zhang, Xiaoli, Yilmaz, Ayse S., Ozer, Hatice G., Valli, Victor E., Vaddi, Kris, Scherle, Peggy, Alinari, Lapo, Kisseberth, William C., Baiocchi, Robert A.
الحاوية / القاعدة PLoS One (2021)

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

بواسطة Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.
الحاوية / القاعدة Cancer Cell (2006)

PRMT5 regulates T cell interferon response and is a target for acute graft-versus-host disease

بواسطة Snyder, Katiri J., Zitzer, Nina C., Gao, Yandi, Choe, Hannah K., Sell, Natalie E., Neidemire-Colley, Lotus, Ignaci, Anora, Kale, Charuta, Devine, Raymond D., Abad, Maria G., Pietrzak, Maciej, Wang, Min, Lin, Hong, Zhang, Yang W., Behbehani, Gregory K., Jackman, Jane E., Garzon, Ramiro, Vaddi, Kris, Baiocchi, Robert A., Ranganathan, Parvathi
الحاوية / القاعدة JCI Insight (2020)

The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis

بواسطة Verstovsek, Srdan, Mesa, Ruben A., Gotlib, Jason, Levy, Richard S., Gupta, Vikas, DiPersio, John F., Catalano, John V., Deininger, Michael, Miller, Carole, Silver, Richard T., Talpaz, Moshe, Winton, Elliott F., Harvey, Jimmie H., Arcasoy, Murat O., Hexner, Elizabeth, Lyons, Roger M., Paquette, Ronald, Raza, Azra, Vaddi, Kris, Erickson-Viitanen, Susan, Sun, William, Sandor, Victor, Kantarjian, Hagop M.
منشور في 2013

Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I

بواسطة Verstovsek, Srdan, Mesa, Ruben A., Gotlib, Jason, Levy, Richard S., Gupta, Vikas, DiPersio, John F., Catalano, John V., Deininger, Michael W.N., Miller, Carole B., Silver, Richard T., Talpaz, Moshe, Winton, Elliott F., Harvey, Jimmie H., Arcasoy, Murat O., Hexner, Elizabeth O., Lyons, Roger M., Raza, Azra, Vaddi, Kris, Sun, William, Peng, Wei, Sandor, Victor, Kantarjian, Hagop
الحاوية / القاعدة Haematologica (2015)

A Double-Blind Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

بواسطة Verstovsek, Srdan, Mesa, Ruben A., Gotlib, Jason, Levy, Richard S., Gupta, Vikas, DiPersio, John F., Catalano, John V., Deininger, Michael, Miller, Carole, Silver, Richard T., Talpaz, Moshe, Winton, Elliott F., Harvey, Jimmie H., Arcasoy, Murat O., Hexner, Elizabeth, Lyons, Roger M., Paquette, Ronald, Raza, Azra, Vaddi, Kris, Erickson-Viitanen, Susan, Koumenis, Iphigenia L., Sun, William, Sandor, Victor, Kantarjian, Hagop M.
الحاوية / القاعدة N Engl J Med (2012)

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

بواسطة Koblish, Holly, Li, Yun-long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther, Gary W., Lambert, Que T., Dostalik Roman, Valerie, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Diamond, Sharon, Hollis, Greg, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy
الحاوية / القاعدة PLoS One (2018)