DNMT3A R882 mutations promote anthracycline resistance in acute myeloid leukemia through impaired nucleosome remodeling

Although the majority of acute myeloid leukemia (AML) patients initially respond to chemotherapy, many patients subsequently relapse; the mechanistic basis for AML persistence following chemotherapy has not been delineated. Recurrent somatic mutations in DNA methyltransferase 3A (DNMT3A), most frequ...

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Publicado no:Nat Med
Main Authors: Guryanova, Olga A., Shank, Kaitlyn, Spitzer, Barbara, Luciani, Luisa, Koche, Richard P., Garrett-Bakelman, Francine E., Ganzel, Chezi, Durham, Benjamin H., Mohanty, Abhinita, Hoermann, Gregor, Rivera, Sharon A., Chramiec, Alan G., Pronier, Elodie, Bastian, Lennart, Keller, Matthew D., Tovbin, Daniel, Loizou, Evangelia, Weinstein, Abby R., Gonzalez, Adriana Rodriguez, Lieu, Yen, Rowe, Jacob M., Pastore, Friederike, McKenney, Anna Sophia, Krivtsov, Andrei V., Sperr, Wolfgang R., Cross, Justin R., Mason, Christopher E., Tallman, Martin S., Arcila, Maria E., Abdel-Wahab, Omar, Armstrong, Scott A., Kubicek, Stefan, Staber, Philipp B., Gönen, Mithat, Paietta, Elisabeth M., Melnick, Ari M., Nimer, Stephen D., Mukherjee, Siddhartha, Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359771/
https://ncbi.nlm.nih.gov/pubmed/27841873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4210
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